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Inhibitors?ScreeningLibraries?Proteins

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2-PMPA(Standard)

Cat.No.:HY-100788R

CASNo.:173039-10-6

Synonyms:2-(Phosphonomethyl)pentanedioicacid(Standard)

分?式:C?H??O?P

分?量:226.12

作?靶点:Carboxypeptidase

作?通路:MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性2-PMPA(Standard)是2-PMPA的分析标准品。本产品?于研究及分析应?。2-PMPA是?效选择性的?氨酸羧

肽酶II(GCPII)抑制剂，IC50值为300pM。

IC50TargetIC50:300pM(GCPII)[1]

REFERENCES

[1].RaisR,etal.BioanalyticalmethodforevaluatingthepharmacokineticsoftheGCP-IIinhibitor2-phosphonomethylpentanedioicacid(2-

PMPA).JPharmBiomedAnal.2014Jan;88:162-9.

[2].ZuoD,etal.Existenceofgliamitigatedketamine-inducedneurotoxicityinneuron-gliamixedculturesofneonatalratcortexandtheglia-

mediatedprotectiveeffectof2-PMPA.Neurotoxicology.2014Sep;44:218-30.

[3].BaslowMH,etal.2-PMPA,aNAAGpeptidaseinhibitor,attenuatesmagneticresonanceBOLDsignalsinbrainofanesthetizedmice:

evidenceofalinkbetweenneuronNAAGreleaseandh