Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
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Fasentin(Standard)
Cat.No.:HY-101849R
CASNo.:392721-37-8
分?式:C??H?ClF?NO?
分?量:279.64
作?靶点:GLUT;TNFReceptor;Apoptosis
作?通路:MembraneTransporter/IonChannel;Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Fasentin(Standard)是Fasentin的分析标准品。本产品?于研究及分析应?。Fasentin是有效的葡萄糖摄取抑
制剂，可抑制GLUT-1/GLUT-4转运蛋?。Fasentin优先抑制GLUT4(IC50=68μM)。Fasentin是死亡受体刺
激(FAS)敏化剂，可敏化细胞对FAS诱导的细胞死亡。Fasentin也是诱导肿瘤坏死因?(TNF)凋亡配体的敏化
剂。Fasentin阻断癌细胞系中的葡萄糖摄取，并具有抗?管?成活性。
REFERENCES
[1].MaCarmenOca?a,etal.Fasentindiminishesendothelialcellproliferation,differentiationandinvasioninaglucosemetabolism-
independentmanner.SciRep.2020Apr9;10(1):6132.
[2].TabithaEWood,etal.AnovelinhibitorofglucoseuptakesensitizescellstoFAS-inducedcelldeath.MolCancerTher.2008
Nov;7(11):3546-55.
[3].QinWu,etal.GLUT1inhibitionblocksgrowthofRB1-positivetriplenegativebreastcancer.NatCommun.2020Aug21;11(1):4205.
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