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Talniflumate(Standard)

Cat.No.:HY-103370R

CASNo.:66898-62-2

Synonyms:BA7602-06(Standard)

分?式:C??H??F?N?O?

分?量:414.33

作?靶点:ChlorideChannel

作?通路:MembraneTransporter/IonChannel

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Talniflumate(Standard)是Talniflumate的分析标准品。本产品?于研究及分析应?。Talniflumate(BA

7602-06)是尼氟酸(HY-B0493)的前体，通过酯酶转化为尼氟酸，从?在体内发挥其活性。Talniflumate是具

有?服活性的Ca2+激活的Cl-通道(CaCC)阻滞剂。Talniflumate可?作远端肠梗阻综合征囊性纤维化??模

型的缓解疼痛和抗炎的研究。

IC50TargetIC50:Ca2+-activatedCl-channel(CaCC)[1]

REFERENCES

[1].Hyun-JiKim,etal.Pharmacokineticsoftalniflumate,aprodrugofniflumicacid,followingoraladministrationtoman.Archivesof

PharmacalResearchvolume19,Articlenumber:297(1996)

[2].Mollereau,etal.AgonistandAntagonistActivitiesonHumanNPFF(2)ReceptorsoftheNPYLigandsGR231118andBIBP3226.BrJ

Pharmacol.2001May;133(1):1-4.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedf