Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
SCH28080(Standard)
Cat.No.:HY-103261R
CASNo.:76081-98-6
分?式:C??H??N?O
分?量:277.32
作?靶点:ProtonPump
作?通路:MembraneTransporter/IonChannel
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性SCH28080(Standard)是SCH28080的分析标准品。本产品?于研究及分析应?。SCH28080是?种可逆的，
K+竞争性的胃H,K-ATPase抑制剂，Ki值为0.12μM。SCH28080在体内是有效的酸分泌抑制剂，具有抗溃
疡作?[1][2][3]。
IC50TargetKi:0.12μM((H+/K+)-ATPase)[1]
REFERENCES
[1].ScottCK,etal.Studiesonthemechanismofactionofthegastricmicrosomal(H++K+)-ATPaseinhibitorsSCH32651andSCH28080.
BiochemPharmacol.1987Jan1;36(1):97-104.
[2].MartinJakab,etal.TheH+/K+ATPaseInhibitorSCH-28080InhibitsInsulinSecretionandInducesCellDeathinINS-1ERatInsulinoma
Cells.CellPhysiolBiochem.2017;43(3):1037-1051.
[3].YHamagishi,etal.InhibitoryEffectsofCopiamycinA,aMacrocyclicLactoneAntibiotic,onGastricH+,K(+)-ATPase,AcidSecretionand
UlcerFormation.JpnJPharmacol.1991Feb;55(2):283-6.
McePdfHeight