Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Aloxistatin(Standard)

Cat.No.:HY-100229R

CASNo.:88321-09-9

Synonyms:E64d(Standard);E64cethylester(Standard)

分?式:C??H??N?O?

分?量:342.43

作?靶点:Cathepsin;SARS-CoV

作?通路:MetabolicEnzyme/Protease;Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Aloxistatin(Standard)是Aloxistatin的分析标准品。本产品?于研究及分析应?。Aloxistatin(E64d)是可渗

透细胞,不可逆的?谱半胱氨酸蛋?酶(cysteineprotease)抑制剂。Aloxistatin(E64d)可抑制MERS-CoV。

IC50TargetCysteineprotease[1]

REFERENCES

[1].Doh-UraK,etal.Lysosomotropicagentsandcysteineproteaseinhibitorsinhibitscrapie-associatedprionproteinaccumulation.JVirol.

2000May;74(10):4894-7.

[2].KonjarS,etal.HumanandmouseperforinareprocessedinpartthroughcleavagebythelysosomalcysteineproteinasecathepsinL.

Immunology.2010Oct;131(2):257-67.

[3].MullinsSR,etal.Three-dimensionalculturesmodelingpremalignantprogressionofhumanbreastepithelialcells:roleofcysteine

cathepsi