基本信息
文件名称：Zidovudine-Glucuronide-13C6-3-Azido-3-deoxythymidine-β-D-glucuronide-sup-13-sup-C-sub-6-sub-生命科学试剂-MCE.pdf
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更新时间：2025-05-22
总字数：约3.11千字
文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

ZidovudineGlucuronide-13C6

Cat.No.:HY-137522AS1

Synonyms:3-Azido-3-deoxythymidineβ-D-glucuronide-13C6

分?式:C????C?H??N?O??

分?量:444.28

作?靶点:Isotope-LabeledCompounds;DrugMetabolite

作?通路:Others;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性ZidovudineGlucuronide-13C6(3-Azido-3-deoxythymidineβ-D-glucuronide-13C6)是13C标记的

ZidovudineO-β-D-glucuronide.ZidovudineO-β-D-glucuronide(3-Azido-3-deoxythymidineβ-D-

glucuronide)sodium是Zidovudine的主要代谢物。Zidovudine是?种核苷逆转录酶抑制剂(NRTI)，可?于

HIV感染的研究。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteri