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Inhibitors?ScreeningLibraries?Proteins

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Voxelotor-d6

Cat.No.:HY-18681S

CASNo.:2170187-39-8

Synonyms:GBT440-d6

分?式:C??H??D?N?O?

分?量:343.41

作?靶点:Isotope-LabeledCompounds;Others

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Voxelotor-d6(GBT440-d6)是氘代标记的Voxelotor.Voxelotor(GBT440)是?种有效的镰状?红蛋?(HbS)

聚合抑制剂。Voxelotor有潜??于镰状细胞贫?病的研究[1]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].OksenbergD,etal.GBT440increaseshaemoglobinoxygenaffinity,reducessicklingandprolongsRBChalf-lifeinamurinemodelof