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Inhibitors?ScreeningLibraries?Proteins
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TDI-012804
Cat.No.:HY-173349
分?式:C??H??N?O?
分?量:506.55
作?靶点:PARP
作?通路:CellCycle/DNADamage;Epigenetics
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性TDI-012804是?种TNKS2抑制剂，对细胞内源性TNKS2蛋?具有选择性抑制作?。TDI-012804增加了
TNKS1杂合?(Tnks1HET)和完全敲除(Tnks1KO)的细胞中AXIN1蛋?的表达。TDI-012804可抑制
ApcQ1405X/Tnks1KO类器官的增殖(EC50为59.1nM)，且对Tnks1KOAKP-G12D和AKP-G13D类器官具有
选择性的毒性[1]。
REFERENCES
[1].JillZimmerman,etal.ApotentandselectiveTNKS2inhibitorfortumor-selectiveWNTsuppression.bioRxiv.2025Mar
7:2025.03.04.641305.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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1/1MasterofBioactiveMolecules—您?边的抑制剂?师