Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
STING-IN-13
Cat.No.:HY-173317
分?式:C??H??F?N?O?
分?量:377.36
作?靶点:STING;InterleukinRelated
作?通路:Immunology/Inflammation
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性STING-IN-13是?种选择性STING抑制剂。STING-IN-13能有效抑制STING通路的下游信号传导，抑制STING
介导的炎症。STING-IN-13毒性较低，可?于STING相关炎症和??免疫性疾病的研究[1]。
体外研究STING-IN-13(CompoundHY2)(30μM)showsdirectinteractionwithSTINGinRAW264.7cells[1].
STING-IN-13(0.03μM-0.3μM,pre-treatfor1h,thenco-incubationfor2-4h)effectivelyinhibitsthe
downstreamsignalingoftheSTINGpathwayinTHP1andRAW264.7cellsinducedbySR717(HY-131454),
andeffectivelyreducestheproductionofinflammatoryfactorsIFN-βandCXCL10[1].
STING-IN-13(0.4μM-3.3μM,48h)hasexcellentsafetyandlowcytotoxicityinTHP1cells[1].
STING-IN-13(5μM,pre-treatfor1h,thentreatfor2h)specificallyinhibitsSTING-drivenIFNβexpressionin
THP1cellswithoutaffectingtheTLRpathway[1].
RealTimeqPCR[1]
CellLine:SR717(30μM)treatedTHP1andRAW264.7cells
Concentration: