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Simotinib(Standard)
Cat.No.:HY-101820R
CASNo.:944258-89-3
分?式:C??H??ClFN?O?
分?量:500.95
作?靶点:EGFR
作?通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Simotinib(Standard)是Simotinib的分析标准品。本产品?于研究及分析应?。Simotinib是?种选择性、特
异性、?服?物利?度?的EGFR酪氨酸激酶抑制剂，IC50为19.9nM。抗肿瘤活性。
REFERENCES
[1].HuXS,etal.Safety,tolerability,andpharmacokineticsofsimotinib,anovelspecificEGFRtyrosinekinaseinhibitor,inpatientswith
advancednon-smallcelllungcancer:resultsofaphaseIbtrial.CancerManagRes.2019;11:4449-4459.Published2019May13.
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