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Inhibitors?ScreeningLibraries?Proteins

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Sildenafil-d5

Cat.No.:HY-15025S3

CASNo.:951385-70-9

Synonyms:UK-92480-d5

分?式:C??H??D?N?O?S

分?量:479.61

作?靶点:Isotope-LabeledCompounds;Autophagy;Bacterial;

Phosphodiesterase(PDE);Apoptosis

作?通路:Others;Autophagy;Anti-infection;Metabolic

Enzyme/Protease;Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Sildenafil-d5(UK-92480-d5)是氘代标记的Sildenafil.Sildenafil(UK-92480)是?种有效的磷酸?酯酶5(

PDE5)抑制剂，IC50为5.22nM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.