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Inhibitors?ScreeningLibraries?Proteins

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SHP099monohydrochloride(Standard)

Cat.No.:HY-100388AR

CASNo.:2200214-93-1

分?式:C??H??Cl?N?

分?量:388.72

作?靶点:SHP2;Phosphatase

作?通路:ProteinTyrosineKinase/RTK;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性SHP099(monohydrochloride)(Standard)是SHP099(monohydrochloride)的分析标准品。本产品?于研究

及分析应?。SHP099hydrochloride是有效，选择性，有?服活性的SHP2抑制剂，IC50值为70nM。

IC50TargetIC50:70nM(SHP2)[1]

REFERENCES

[1].GarciaFortanetJ,etal.AllostericInhibitionofSHP2:IdentificationofaPotent,Selective,andOrallyEfficaciousPhosphataseInhibitor.J

MedChem.2016Sep8;59(17):7773-82.

[2].ChenYN,etal.AllostericinhibitionofSHP2phosphataseinhibitscancersdrivenbyreceptortyrosinekinases.Nature.2016Jul

7;535(7610):148-52.

[3].CarmineFedele,etal.SHP2InhibitionAbrogatesMEKinhibitorResistanceinMultipleCancerModels.bioRxiv.April25,2018.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.