Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Safinamide-d5

Cat.No.:HY-70057S4

Synonyms:FCE26743-d;EMD1195686-d

55

分?式:C??H??D?FN?O?

分?量:307.37

作?靶点:Isotope-LabeledCompounds;MonoamineOxidase

作?通路:Others;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Safinamide-d5(FCE26743-d5)是氘代标记的Safinamide.Safinamide是?种有效的、选择性的、可逆的单胺

氧化酶B(MAO-B)的抑制剂(IC50=0.098μM)，对MAO-A(IC50=580μM)选择性较低。Safinamide也阻断

钠通道和调节?氨酸(Glu)释放，在去极化时(IC50=8μM)?静息电位(IC50=262μM)时，显?出更?的亲

和?。Safinamide具有神经保护作?，可?于帕?森病、缺?脑卒中等疾病的研究。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES