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Rizatriptanhemisulfatehemihydrate

Cat.No.:HY-W018475B

CASNo.:159776-67-7

Synonyms:MK462hemisulfatehemihydrate

分?式:C??H??N?.?/?H?O?S.?/?H?O

分?量:327.39

作?靶点:5-HTReceptor

作?通路:GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Rizatriptan(MK462)hemisulfatehemihydrate是5-HT1B和5-HT1D的激动剂。Rizatriptanhemisulfate

hemihydrate具有外周?管收缩作?，可穿透完整的?脑屏障，并抑制中枢神经系统的疼痛神经传递[1][2]。

REFERENCES

[1].SciberrasDG,etal.InitialhumanexperiencewithMK-462(rizatriptan):anovel5-HT1Dagonist.BrJClinPharmacol.1997

Jan;43(1):49-54.

[2].CumberbatchMJ,etal.Rizatriptanhascentralantinociceptiveeffectsagainstdurallyevokedresponses.EurJPharmacol.1997Jun

5;328(1):37-40.

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