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Inhibitors?ScreeningLibraries?Proteins

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Revefenacin-d4

Cat.No.:HY-15851S3

Synonyms:TD-4208-d;GSK1160724-d

44

分?式:C??H??D?N?O?

分?量:601.77

作?靶点:Isotope-LabeledCompounds

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Revefenacin-d4(TD-4208-d4)是氘代标记的Revefenacin.Revefenacin(TD-4208;GSK1160724)是有效的

mAChR拮抗剂，在M3受体上具有?亲和?，Ki值为0.18nM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.