Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

PI-103Hydrochloride(Standard)

Cat.No.:HY-10115AR

CASNo.:371935-79-4

分?式:C??H??ClN?O?

分?量:384.82

作?靶点:PI3K;mTOR;DNA-PK;Autophagy;Apoptosis

作?通路:PI3K/Akt/mTOR;CellCycle/DNADamage;Autophagy;

Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性PI-103(Hydrochloride)(Standard)是PI-103(Hydrochloride)的分析标准品。本产品?于研究及分析应?。PI-

103Hydrochloride是?种有效的PI3K和mTOR抑制剂，抑制p110α，p110β，p110δ，p110γ，

mTORC1和mTORC2，IC50分别为8nM，88nM，48nM，150nM，20nM和83nM。PI-103

Hydrochloride也可抑制DNA-PK，IC50为2nM。PI-103Hydrochloride诱导?噬(autophagy)[1][2][3]

[4]。

IC50TargetIC50:8nM(p110α),88nM(p110β),48nM(p110δ),150nM(p110γ),2nM(DNA-PK),20nM(mTORC1),83

nM(mTORC2),26nM(PI3KC2β),850nM(ATR),920nM(ATM),~1μM(PI3KC2α),2.3μM(hsVPS34),~50

μM(PI4KIIIβ)[4]

REFERENCES

[1].RaynaudFI,etal.Biologicalpr