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Inhibitors?ScreeningLibraries?Proteins

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Perindopril-d5

Cat.No.:HY-B0130S1

Synonyms:S-9490-d5

分?式:C??H??D?N?O?

分?量:373.5

作?靶点:Isotope-LabeledCompounds;Sirtuin;Angiotensin-converting

Enzyme(ACE);NF-κB;STAT

作?通路:Others;CellCycle/DNADamage;Epigenetics;Metabolic

Enzyme/Protease;NF-κB;JAK/STATSignaling;StemCell/Wnt

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Perindopril-d5(S-9490-d5)是氘代标记的Perindopril.Perindopril(S-9490)是?种?服有效的长效?管紧张

素转换酶(ACE)抑制剂。Perindopril能够抑制炎症细胞流?和内膜增厚，保存主动脉内侧弹性蛋?。

Perindopril有效抑制??模型中实验性腹主动脉瘤(AAA)形成、降低肺动脉?压??的肺?管收缩。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].BhatSA,etal.AngiotensinreceptorblockademodulatesNFκBandSTAT3signalingandinhibitsg