基本信息
文件名称：Laninamivir-13C-15N2-R-125489-sup-13-sup-C-sup-15-sup-N-sub-2-sub-生命科学试剂-MCE.pdf
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更新时间：2025-05-22
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Laninamivir-13C,15N2

Cat.No.:HY-14818S1

Synonyms:R125489-13C,15N2

分?式:C????CH??N???N?O?

分?量:349.32

作?靶点:Isotope-LabeledCompounds;InfluenzaVirus

作?通路:Others;Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Laninamivir-13C,15N2(R125489-13C,15N2)是13C和15N标记的Laninamivir.Laninamivir(R125489)是?

种有效的流感神经氨酸酶(NA)抑制剂，其对流感病毒H12N5NA(N5)，pH1N1N1NA(p09N1)和

A/RI/5+/1957H2N2N2(p57N2)的IC50分别为0.90nM、1.83nM和3.12nM[1]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].Va