Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Ketoprofen-13C6

Cat.No.:HY-B0227S3

CASNo.:1261392-46-4

Synonyms:RP-19583-13C6

分?式:C????C?H??O?

分?量:260.24

作?靶点:Isotope-LabeledCompounds;COX

作?通路:Others;Immunology/Inflammation

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Ketoprofen-13C6(RP-19583-13C6)是13C标记的Ketoprofen.Ketoprofen(RP-19583)是?种?甾体抗炎剂

，可抑制cyclooxygenase的活性，其IC50值为2nM(COX-1)和26nM(COX-2)。Ketoprofen可?于炎症、

免疫学和代谢性疾病(如肥胖)的相关研究[1][2][3]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[