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Inhibitors?ScreeningLibraries?Proteins

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Indomethacin-13C6

Cat.No.:HY-14397S3

Synonyms:Indometacin-13C6

分?式:C????C?H??ClNO?

分?量:363.74

作?靶点:Isotope-LabeledCompounds;COX;Antibiotic;InfluenzaVirus;

Bacterial

作?通路:Others;Immunology/Inflammation;Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Indomethacin-13C6(Indometacin-13C6)是13C标记的Indomethacin.Indomethacin(Indometacin)是?种

有效的?服活性COX1/2抑制剂，COX-1和COX-2的IC50值分别为18nM和26nM。Indomethacin具有抗

癌和抗感染活性。Indomethacin可?于癌症、炎症和病毒感染的研究。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].HellebergL,et,al.ClinicalPharmacokineticsofindomethacin.ClinPharmacokinet.1981Jul-Aug;6(4):245-58.

[3].SabiuS,et,al.Indomethacin-inducedgastriculcerationinra