Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
IC-87114(Standard)
Cat.No.:HY-10110R
CASNo.:371242-69-2
分?式:C??H??N?O
分?量:397.43
作?靶点:PI3K
作?通路:PI3K/Akt/mTOR
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性IC-87114(Standard)是IC-87114的分析标准品。本产品?于研究及分析应?。IC-87114是?种有效的选择性
PI3Kδ抑制剂，IC50为0.5μM。
IC50TargetIC50:0.5μM(PI3Kδ)[1]
REFERENCES
[1].SadhuC,etal.Essentialroleofphosphoinositide3-kinasedeltainneutrophildirectionalmovement.JImmunol.2003Mar
1;170(5):2647-54.
[2].ZhengL,etal.InactivationofPI3KδinducesvascularinjuryandpromotesaneurysmdevelopmentbyupregulatingtheAP-1/MMP-12
pathwayinmacrophages.ArteriosclerThrombVascBiol.2015Feb;35(2):368-77.
[3].El-HashimAZ,etal.Src-dependentEGFRtransactivationregulateslunginflammationviadownstreamsignalinginvolvingERK1/2,PI3K
δ/AktandNFκBinductioninamurineasthmamodel.SciRep.2017Aug30;7(1):9919.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.