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Histamine-d4

Cat.No.:HY-B1204S1

CASNo.:751471-48-4

Synonyms:Ergamine-d4

分?式:C?H?D?N?

分?量:115.17

作?靶点:Isotope-LabeledCompounds;EndogenousMetabolite;

HistamineReceptor

作?通路:Others;MetabolicEnzyme/Protease;GPCR/GProtein;

Immunology/Inflammation;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Histamine-d4(Ergamine-d4)是氘代标记的Histamine.Histamine是?种参与局部免疫反应的有机含氮化合物

,调节肠道?理功能,且作为神经递质。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-