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Inhibitors?ScreeningLibraries?Proteins

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Febuxostat-d5

Cat.No.:HY-14268S3

Synonyms:TEI6720-d;TMX67-d

55

分?式:C??H??D?N?O?S

分?量:321.41

作?靶点:Isotope-LabeledCompounds;XanthineOxidase

作?通路:Others;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Febuxostat-d5(TEI6720-d5)是氘代标记的Febuxostat.Febuxostat(TEI6720)是?种有效的、选择性的、?

嘌呤黄嘌呤氧化酶(XO)抑制剂，Ki值为0.6nM。Febuxostat具有研究?尿酸?症和痛风的潜?[1][2][3]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

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