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Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
DHFR-IN-23
Cat.No.:HY-173220
分?式:C??H??ClN?O?S
分?量:383.85
作?靶点:Dihydrofolatereductase(DHFR);Apoptosis
作?通路:MetabolicEnzyme/Protease;Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性DHFR-IN-23(compound5)是DNAbinders/DHFR的双抑制剂，其对hDHFR的IC50值为0.08μM。DHFR-
IN-23(compound5)是凋亡诱导剂，可?于ER+乳腺癌研究。
体外研究DHFR-IN-23(compound5)exhibitsanIC50of2.72μg/mLforMCF-7cells[1].
REFERENCES
[1].MarwaH,etal.Rationaldesign,synthesis,andmolecularmodellinginsightsofdualDNAbinders/DHFRinhibitorsbearingarylidene-
hydrazinyl-1,3-thiazolescaffoldwithapoptoticandanti-migratorypotentialinbreastMCF-7cancercells.JournalofEnzymeInhibitionand
MedicinalChemistryVolume40,2025-Issue1.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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