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Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Danusertib(Standard)

Cat.No.:HY-10179R

CASNo.:827318-97-8

Synonyms:PHA-739358(Standard)

分?式:C??H??N?O?

分?量:474.55

作?靶点:AuroraKinase;Autophagy

作?通路:CellCycle/DNADamage;Epigenetics;Autophagy

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Danusertib(Standard)是Danusertib的分析标准品。本产品?于研究及分析应?。Danusertib是?种极光激

酶(aurorakinase)抑制剂，能够抑制AuroraA，AuroraB和AuroraC的活性，IC50值分别为13，79和61

nM。

IC50TargetIC50:13nM(AuroraA),79nM(AuroraB),61nM(AuroraC)[1]

REFERENCES

[1].ZiD,etal.DanusertibInducesApoptosis,CellCycleArrest,andAutophagybutInhibitsEpithelialtoMesenchymalTransitionInvolving

PI3K/Akt/mTORSignalingPathwayinHumanOvarianCancerCells.IntJMolSci.2015Nov13;16(11):27228-51.

[2].GontarewiczA,etal.SimultaneoustargetingofAurorakinasesandBcr-AblkinasebythesmallmoleculeinhibitorPHA-739358is

effectiveagainstimatinib-resistantBCR-ABLmutationsincludingT315I.Blood.2008Apr15;1