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Coprostanone

Cat.No.:HY-W588187

CASNo.:601-53-6

Synonyms:5β-Cholestan-3-one

分?式:C??H??O

分?量:386.65

作?靶点:DrugMetabolite;Apoptosis

作?通路:MetabolicEnzyme/Protease;Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Coprostanone(5β-cholestan-3-one)是?种羟甾醇和Cholesterol(HY-N0322)的活性代谢物。

Coprostanone诱导?原代胆囊上?细胞凋亡(apoptosis)。Coprostanone有望?于结肠癌或腺瘤性息?的研

究[1][2]。

REFERENCES

[1].SeoDW,etal.Oxysterolsfromhumanbileinduceapoptosisofcaninegallbladderepithelialcellsinmonolayerculture.AmJPhysiol

GastrointestLiverPhysiol.2004Dec;287(6):G1247-56.

[2].ReddyBS,etal.Metabolicepidemiologyofcoloncancer.Fecalbileacidsandneutralsterolsincoloncancerpatientsandpatientswith

adenomatouspolyps.Cancer.1977Jun;39(6):2533-9.

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