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Inhibitors?ScreeningLibraries?Proteins

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Cilostazol-d2

Cat.No.:HY-17464S2

CASNo.:1073608-03-3

Synonyms:OPC13013-d2

分?式:C??H??D?N?O?

分?量:371.47

作?靶点:Isotope-LabeledCompounds;Autophagy;Phosphodiesterase

(PDE)

作?通路:Others;Autophagy;MetabolicEnzyme/Protease

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Cilostazol-d2(OPC13013-d2)是氘代标记的Cilostazol.Cilostazol(OPC13013)是有效、选择性的??管系统

中磷酸?酯酶3亚型PDE3A的抑制剂，IC50值为0.2μM[1][2]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.