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BrefeldinA4-O-nicotinate

Cat.No.:HY-173280

CASNo.:3035018-34-6

Synonyms:CHNQD-01228

分?式:C??H??NO?

分?量:385.45

作?靶点:ArfFamilyGTPase;BMXKinase

作?通路:GPCR/GProtein;ProteinTyrosineKinase/RTK

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性BrefeldinA4-O-nicotinate(CHNQD-01228)是?种Arf1和BMX蛋?的双重抑制剂，对T24细胞增殖的IC50

值为0.22μM，还能剂量依赖性抑制T24细胞迁移和集落形成、诱导G1期阻滞并触发细胞凋亡(

Apoptosis)；BrefeldinA4-O-nicotinate通过靶向BMX蛋?抑制AKT/p-AKT和STAT3/p-STAT3信号通路，以

及抑制Arf1蛋?来消除膀胱癌?细胞、激活抗肿瘤免疫，从?发挥抗癌活性。BrefeldinA4-O-nicotinate可

?于膀胱癌相关领域的研究[1]。

REFERENCES

[1].LiuJY,etal.NiacinEsterDerivativeofBrefeldinAasaPotentialDual-TargetArf1/BMXInhibitorforBladderCancer.JNatProd.2025

Mar28;88(3):830-841.

McePdfHeight

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