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Inhibitors?ScreeningLibraries?Proteins

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Betrixaban-13C6

Cat.No.:HY-10268S2

Synonyms:PRT054021-13C6

分?式:C????C?H??ClN?O?

分?量:457.86

作?靶点:Isotope-LabeledCompounds

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Betrixaban-13C6(PRT054021-13C6)是13C标记的Betrixaban.Betrixaban(PRT054021)是?种有效的，具

有?服活性的选择性factorXa(fXa)抑制剂，IC50为1.5nM。Betrixaban具有抗?栓形成效果。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

For