Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
BAPTA-AM(Standard)
Cat.No.:HY-100545R
CASNo.:126150-97-8
分?式:C??H??N?O??
分?量:764.68
作?靶点:PotassiumChannel
作?通路:MembraneTransporter/IonChannel
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性BAPTA-AM(Standard)是BAPTA-AM的分析标准品。本产品?于研究及分析应?。BAPTA-AM是?种可透过
细胞膜的钙螯合剂(Ca2+chelator)。在HEK293细胞中，BAPTA-AM阻断hERG，hKv1.3和hKv1.5通道，
IC50分别为1.3，1.45和1.23μM[1]。
IC50TargetCa2+chelator[1]
IC50:1.3μM(hERGchannel,inHEK293cells),1.45μM(hKv1.3,inHEK293cells),1.23μM(hKv1.5,in
HEK293cells)[1]
REFERENCES
[1].WieMB,etal.BAPTA/AM,anintracellularcalciumchelator,inducesdelayednecrosisbylipoxygenase-mediatedfreeradicalsinmouse
corticalcultures.ProgNeuropsychopharmacolBiolPsychiatry.2001Nov;25(8):1641-59.
[2].TangQ,etal.ThemembranepermeablecalciumchelatorBAPTA-AMdirectlyblockshumanethera-go-go-relatedgenepotassium
channelsstablyexpressedinHEK293cell