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Aprepitant-13C2,d2(Major)

Cat.No.:HY-W777166

CASNo.:1217676-37-3

Synonyms:MK-0869--13C,d;MK-869-13C,d;L-754030--13C,d

222222

分?式:C????C?H??D?F?N?O?

分?量:538.42

作?靶点:Isotope-LabeledCompounds;Bacterial;NeurokininReceptor;

Antibiotic;HIV

作?通路:Others;Anti-infection;GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Aprepitant-13C2,d2(Major)(MK-0869-13C2,d2)是13C标记的Aprepitant.Aprepitant(MK-0869)是选择性

和?亲和?的神经激肽1受体拮抗剂，Kd值为86pM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.