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Inhibitors?ScreeningLibraries?Proteins
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Antitumoragent-201
Cat.No.:HY-173331
分?式:C??H??F?N?O?S
分?量:592.51
作?靶点:ChlorideChannel;Apoptosis;Autophagy
作?通路:MembraneTransporter/IonChannel;Apoptosis;Autophagy
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Antitumoragent-201(Compound10)是?种靶向?尔基体的氯离?转运激活剂，其促进氯离?跨膜转运的
EC50为1.53mol%，对HepG2细胞的IC50为7.13μM。Antitumoragent-201通过选择性地作?于?尔基
体，破坏其内部氯离?稳态，降低GM130和GRASP55等关键蛋?的表达，改变?尔基体的结构和功能，引
发?尔基体?噬()，进?诱导癌细胞凋亡(Apoptosis)，并使癌细胞阻滞于G2/M期，发挥抗癌活性。
Antitumoragent-201可?于癌症疾病领域的研究[1]。
REFERENCES
[1].YangH,etal.Design,synthesisandbiologicalevaluationofGolgi-targetinganiontransportersasinducersofGolgiphagyandapoptosis
incancercells.EurJMedChem.2025Jun5;290:117519.
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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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