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2-Methoxyidazoxanmonohydrochloride(Standard)

Cat.No.:HY-103197R

CASNo.:109544-45-8

Synonyms:RX821002hydrochloride(Standard)

分?式:C??H??ClN?O?

分?量:270.71

作?靶点:AdrenergicReceptor

作?通路:GPCR/GProtein;NeuronalSignaling

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性2-Methoxyidazoxan(monohydrochloride)(Standard)是2-Methoxyidazoxan(monohydrochloride)的分析

标准品。本产品?于研究及分析应?。2-Methoxyidazoxanmonohydrochloride(RX821002hydrochloride)

是?种?选择性alpha2r肾上腺素受体拮抗剂，对imidazoline拮抗作?很?或没有。2-Methoxyidazoxan

monohydrochloride对(豚?)alpha2D肾上腺素受体(pKd9.7)的亲和?明显?于(兔?)alpha2A肾上腺素

受体(pKd8.2)。

REFERENCES

[1].HeadGA.Importanceofimidazolinereceptorsinthecardiovascularactionsofcentrallyactingantihypertensiveagents.AnnNYAcad

Sci.1995;763:531-540.

[2].TrendelenburgAU,etal.Antagoniststhatdifferentiatebetweenalpha2A-andalpha2D-adrenoceptors.NaunynSchmiedebergsArch

Pharmacol.1996;353(3):245-249.