基本信息
文件名称：Tofacitinib-13C-d3-Tasocitinib-sup-13-sup-C-d-sub-3-sub-生命科学试剂-MCE.pdf
文件大小：457.12 KB
总页数：1 页
更新时间：2025-05-22
总字数：约2.37千字
文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Tofacitinib-13C,d3

Cat.No.:HY-40354S2

Synonyms:Tasocitinib-13C,d;CP-690550-13C,d

33

分?式:C????CH??D?N?O

分?量:316.38

作?靶点:Isotope-LabeledCompounds

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Tofacitinib-13C,d3(Tasocitinib-13C,d3)是13C标记的Tofacitinib.Tofacitinib是JAK3/2/1抑制剂，IC50分别

为1，20和112nM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapp