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Terbinafine-d3

Cat.No.:HY-17395AS1

CASNo.:1133210-36-2

Synonyms:TDT067-d3

分?式:C??H??D?N

分?量:294.45

作?靶点:Isotope-LabeledCompounds;Antibiotic;Fungal;Bacterial

作?通路:Others;Anti-infection

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Terbinafine-d3(TDT067-d3)是氘代标记的Terbinafine.Terbinafine(TDT067)是?种?服有效的抗真菌剂(

antifungalagent)。Terbinafine是?种对Candida的?鲨烯环氧化酶的有效?竞争性抑制剂，其Ki为30

nM。Terbinafine对某些?兰?阳性和?兰?阴性细菌也有抗菌活性[1][2][3]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-