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Simvastatinacid-d6

Cat.No.:HY-119695S

CASNo.:2747915-75-7

Synonyms:Tenivastatin-d6

分?式:C??H??D?O?

分?量:442.62

作?靶点:Isotope-LabeledCompounds;HMG-CoAReductase

(HMGCR);ReactiveOxygenSpecies

作?通路:Others;MetabolicEnzyme/Protease;

Immunology/Inflammation;NF-κB

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Simvastatinacid-d6(Tenivastatin-d6)是氘代标记的Simvastatinacid.Simvastatinacid

(Tenivastatin)，Simvastatin(HY-17502)的?解产物，是?种有效的HMG-CoA还原酶(HMGCR)抑制剂。

Simvastatinacid降低吲哚酚硫酸盐(Indoxylsulfate)介导的活性氧(ROS)产?。Simvastatinacid也可调节?

肌细胞和转染OATP3A1基因的HEK293细胞的OATP3A1表达。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspot