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文件名称：Naloxegol-13C-d3-NKTR-118-sup-13-sup-C-sub-d-sub-3-sub-生命科学试剂-MCE.pdf
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更新时间：2025-05-22
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文档摘要

Hotline:400-820-3792

Inhibitors?ScreeningLibraries?Proteins

www.MedChemE

Naloxegol-13C,d3

Cat.No.:HY-A0118S

Synonyms:NKTR-118-13C,d;AZ13C

3,d3

分?式:C????CH??D?NO??

分?量:655.8

作?靶点:Isotope-LabeledCompounds

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Naloxegol-13C,d3(NKTR-118-13C,d3)是13C标记的Naloxegol.Naloxegol(NKTR-118;AZ是?

种μ-阿?受体拮抗剂。Naloxegol能抑制阿?结合胃肠道μ-阿?受体，能有效减轻阿?类药物引起的便秘

[1][2]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacoth