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M6903
Cat.No.:HY-P991198
作?靶点:Tim3
作?通路:Immunology/Inflammation
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性M6903是?种?源化的IgG2单克隆抗体，靶向T细胞免疫球蛋?和粘蛋?结构域3(TIM-3)(?TIM-3的KD
为2.3nM)。M6903与TIM-3结合，阻断TIM-3与磷脂酰丝氨酸(PtdSer)、癌胚抗原细胞粘附相关分?1(
CEACAM1)、凝集素9(Gal-9)的结合，从?缓解TIM-3介导的T细胞抑制，发挥抗原特异性T细胞活化活性
，增强抗肿瘤免疫。M6903有望?于癌症的研究[1]。
REFERENCES
[1].ZhangD,etal.IdentificationandcharacterizationofM6903,anantagonisticanti-TIM-3monoclonalantibody.Oncoimmunology.2020
Apr1;9(1):1744921.
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