Hotline:400-820-3792
Inhibitors?ScreeningLibraries?Proteins
www.MedChemE
IXA62
Cat.No.:HY-176040
CASNo.:956783-34-9
分?式:C??H??N?O?
分?量:401.46
作?靶点:IRE1;Amyloid-β
作?通路:CellCycle/DNADamage;NeuronalSignaling
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性IXA62是具有?服活性的、选择性的IRE1/XBP1s激动剂(EC50=0.31μM)，可减少Aβ分泌。
体外研究IXA62isaselectiveIRE1/XBP1sactivatorthatreducesAβsecretionfromCHO7PA2cellsandenhances
glucose-stimulatedinsulinsecretionfromratinsulinomacells,mimickingtheeffectsofIXA4intheseassays
[1].
体内研究IXA62(orally,ori.p,50mg/kg)robustlyandselectivelyactivatesIRE1/XBP1ssignalingintheliverofmice
[1].
REFERENCES
[1].JieSun,etal.IdentificationofaSelectivePharmacologicIRE1/XBP1sActivatorwithEnhancedTissueExposure.ACSChemBiol.2025
Apr15.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.