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Himachalol
Cat.No.:HY-N15424
CASNo.:1891-45-8
分?式:C??H??O
分?量:222.37
作?靶点:Apoptosis;Bcl-2Family
作?通路:Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Himachalol，?种倍半萜烯，是?种?服有效的解痉和抗癌成分，存在于雪松?材中。Himachalol对??素
瘤细胞具有抗增殖活性，并诱导细胞凋亡(Apoptosis)(降低Bcl-2?平并增加Bax?平)。Himachalol具有全
?性降?压和外周?管扩张作?。Himachalol可抑制卡巴胆碱引起的肠道痉挛。Himachalol在??中的LD50
为265mg/kg(?服)和247mg/kg(腹腔注射)。
REFERENCES
[1].ShebabyW,etal.HimachalolinducesapoptosisinB16-F10murinemelanomacellsandprotectsagainstskincarcinogenesis.J
Ethnopharmacol.2020May10;253:112545.
[2].KarK,etal.SpasmolyticconstituentsofCedrusdeodara(Roxb.)Loud:pharmacologicalevaluationofhimachalol.JPharmSci.1975
Feb;64(2):258-262.
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