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Inhibitors?ScreeningLibraries?Proteins

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Goserelin-d7

Cat.No.:HY-13673S1

Synonyms:ICI118630-d7

分?式:C??H??D?N??O??

分?量:1276.45

作?靶点:Isotope-LabeledCompounds;GnRHReceptor;Apoptosis

作?通路:Others;GPCR/GProtein;Apoptosis

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Goserelin-d7(ICI118630-d7)是氘代标记的Goserelin.Goserelin(ICI118630)是?种促性腺激素释放激素(

GnRH/LHRH)?肽类似物，能作为GnRH激动剂。Goserelin可?于乳腺癌、上?性卵巢癌和前列腺癌的研究

[1][2]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

[2].NingZhang,etal.Goserelinpromotestheapo