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Eplerenone-13C,d3

Cat.No.:HY-B0251S1

Synonyms:Epoxymexrenone-13C,d3

分?式:C????CH??D?O?

分?量:418.5

作?靶点:Isotope-LabeledCompounds;MineralocorticoidReceptor;

EndogenousMetabolite

作?通路:Others;MetabolicEnzyme/Protease;VitaminD

Related/NuclearReceptor

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Eplerenone-13C,d3(Epoxymexrenone-13C,d3)是13C标记的Eplerenone.Eplerenone(Epoxymexrenone)

是?种选择性和?度特异性醛固酮阻滞剂(SAB)，具有?服活性。Eplerenone也是?种选择性矿糖?质激素受

体拮抗剂(MRA)，其IC50值为0.081μM。Eplerenone可?于??压、动脉粥样硬化、慢性收缩期??衰竭(

HF)和??管(CV)的研究。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

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