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Inhibitors?ScreeningLibraries?Proteins

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Cibenzoline-d4

Cat.No.:HY-106577S

Synonyms:Cifenline-d;Ro22-7796-d

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分?式:C??H??D?N?

分?量:266.37

作?靶点:Isotope-LabeledCompounds;PotassiumChannel

作?通路:Others;MembraneTransporter/IonChannel

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Cibenzoline-d4(Cifenline-d4)是氘代标记的Cibenzoline.Cibenzoline是Ia类抗?律失常活性分?，其抗胆

碱能活性较低。Cibenzoline是KATP通道抑制剂，通过成孔亚基Kir6.2发挥作?，IC50为22.2μM。

Cibenzoline可抑制IKr和IKs电流，IC50分别为8.8μM和12.3μM。Cibenzoline可?于?肌疾病的研究。

此外，Cibenzoline还具有降?糖的作?[1][2][3][4]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

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