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AZD0516
Cat.No.:HY-173639
作?靶点:Antibody-DrugConjugates(ADCs);Topoisomerase
作?通路:Antibody-drugConjugate/ADCRelated;CellCycle/DNA
Damage
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性AZD0516是?款靶向前列腺六跨膜上?抗原2(STEAP2)的?创抗体-药物偶联物(ADC)。由抗STEAP2单克隆
抗体(mAb)通过链间半胱氨酸与马来酰亚胺反应性、β-葡萄糖醛酸酶可裂解的连接?(HY-173635)和拓扑异
构酶1抑制剂Exatecan(HY-13631)偶联?成。AZD0516可?于前列腺癌的研究。
REFERENCES
[1].1158-PreclinicalcharacterizationofAZD0516,anovelSTEAP2antibody-drugconjugate(ADC)forthetreatmentofprostatecancer.
AACRAnnualMeeting2025ItineraryPlannerHome.
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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
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