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Fluralaner-d3

Cat.No.:HY-16973S4

Synonyms:A1443-d;AH252723-d

33

分?式:C??H??D?Cl?F?N?O?

分?量:559.3

作?靶点:Isotope-LabeledCompounds

作?通路:Others

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Fluralaner-d3(A1443-d3)是氘代标记的Fluralaner.Fluralaner(INN)是?种全?性杀?剂和杀螨剂，通过有效

阻断GABA和L-glutamate氯化物通道。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-

216.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.