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Inhibitors?ScreeningLibraries?Proteins

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GardiquimoddiTFA(Standard)

Cat.No.:HY-103697AR

CASNo.:1159840-61-5

分?式:C??H??F?N?O?

分?量:541.44

作?靶点:Toll-likeReceptor(TLR)

作?通路:Immunology/Inflammation

储存?式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

?物活性Gardiquimod(diTFA)(Standard)是Gardiquimod(diTFA)的分析标准品。本产品?于研究及分析应?。

GardiquimoddiTFA是?种咪唑啉类TLR7/8激动剂。GardiquimoddiTFA可抑制巨噬细胞和活化外周?单个

核细胞(PBMCs)的HIV-1感染。当浓度低于10μM时，GardiquimoddiTFA可以特异性激活TLR7。

IC50TargetTLR7,HIV-1reversetranscriptase[1]

REFERENCES

[1].BuitendijkM,etal.Gardiquimod:aToll-likereceptor-7agonistthatinhibitsHIVtype1infectionofhumanmacrophagesandactivatedT

cells.AIDSResHumRetroviruses.2013Jun;29(6):907-18.

[2].MaF,etal.TheTLR7agonistsimiquimodandgardiquimodimproveDC-basedimmunotherapyformelanomainmice.CellMol

Immunol.2010Sep;7(5):381-8.

[3].ZhouZ,etal.TLR7/8agonistspromoteNK-DCcross-talktoenhanceNKcellanti-tumoreffectsinhepatocellularcarcinoma.Cancer

Lett.2