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Cladribine-15N
Cat.No.:HY-13599S2
CASNo.:1360874-38-9
Synonyms:2-Chloro-2′-deoxyadenosine-15N;Cldado-15N;2Cda-15N
分?式:C??H??ClN???NO?
分?量:286.68
作?靶点:Isotope-LabeledCompounds;Apoptosis;Adenosine
Deaminase
作?通路:Others;Apoptosis;MetabolicEnzyme/Protease
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性Cladribine-15N(2-Chloro-2′-deoxyadenosine-15N)是15N标记的Cladribine.Cladribine(2-Chloro-2′-
deoxyadenosine)是?种嘌呤核苷类似物,是具有?服活性的腺苷脱氨酶(adenosinedeaminase)抑制剂。
Cladribine能作为DNA合成(DNAsynthesis)的抑制剂,可阻断受损DNA的修复。Cladribine可以抑制DNA
甲基化。Cladribine具有抗淋巴瘤活性,可?于?些?液恶性肿瘤和多发性硬化的研究[1][2]。
体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,
largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention
becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.
REFERENCES
[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-
216.
[2].LinyanXu,etal.CladribineInduces