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Inhibitors?ScreeningLibraries?Proteins
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PSF-IN-2
Cat.No.:HY-173177
CASNo.:185418-37-5
分?式:C??H??O?
分?量:312.32
作?靶点:Apoptosis;MDM-2/p53
作?通路:Apoptosis
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性PSF-IN-2(Compound(C)-30)是?种PSF抑制剂，IC50值为0.005pM。PSF-IN-2具有抗癌活性，对22Rv1细
胞增殖抑制的IC50值为0.5μM。PSF-IN-2通过抑制PSF与RNA结合，来激活p53信号通路，诱导相关基因
表达，促进细胞凋亡(Apoptosis)，抑制细胞周期。PSF-IN-2可?于癌症领域的研究[1]。
REFERENCES
[1].TakayamaKI,etal.InhibitionofPSFActivityOvercomesResistancetoTreatmentinCancersHarboringMutantp53.MolCancerTher.
2025Mar4;24(3):370-383.
McePdfHeight
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1/1MasterofBioactiveMolecules—您?边的抑制剂?师