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Inhibitors?ScreeningLibraries?Proteins
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NLRP3-IN-73
Cat.No.:HY-173209
分?式:C??H??FN?O?
分?量:443.47
作?靶点:NOD-likeReceptor(NLR)
作?通路:Immunology/Inflammation
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性NLRP3-IN-73(W16)是?种可?服的、NLRP3炎症?体的组装抑制剂，对NLRP3/IL-1β通路的IC50值为0.18
μM。
体外研究NLRP3-IN-73(W16)dose-dependentlyinhibitsthereleaseofIL-1βinJ774A.1,BMDMsandhuman
peripheralbloodcells[1].
体内研究NLRP3-IN-73(W16:7.5mg/kg,15mg/kg,and30mg/kg,orally)haspotentanti-inflammatoryeffectson
DSS-inducedulcerativecolitismodel[1].
REFERENCES
[1].RuiwenWu,etal.Discovery,synthesis,andbiologicalmechanismevaluationofnovelquinolinederivativesaspotentNLRP3inhibitors.
EurJMedChem.2025May5:289:117466.
McePdfHeight
Caution:Producthasnotbeenfullyvalidatedformedicalapplications.
Forresearchuseonly.
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