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C-021(Standard)
Cat.No.:HY-103364R
CASNo.:864289-85-0
分?式:C??H??N?O?
分?量:467.65
作?靶点:CCR
作?通路:GPCR/GProtein;Immunology/Inflammation
储存?式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
?物活性C-021(Standard)是C-021的分析标准品。本产品?于研究及分析应?。C-021是有效的CC趋化因?受体4(
CCR4)拮抗剂。C-021有效抑制?和??的功能趋化性，IC50分别为140nM和39nM。C-021以IC50为18
nM来有效阻??CCL22衍?的[35S]GTPγS与受体结合。
REFERENCES
[1].YokoyamaK,etal.PotentandorallybioavailableCCR4antagonists:Synthesisandstructure-activityrelationshipstudyof2-
aminoquinazolines.BioorgMedChem.2009Jan1;17(1):64-73.
[2].MatthewMcMillin,etal.NeuronalCCL2isupregulatedduringhepaticencephalopathyandcontributestomicrogliaactivationand
neurologicaldecline.JNeuroinflammation.2014Jul10;11:121.
McePdfHeight
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